Sam Lohse

CWU Courses Taught

Quantitative Analysis
Environmental Chemistry
Advanced Analytical Chemistry

Education

PhD Chemistry, University of Oregon (2011)

Dissertation Title: “Direct synthesis of thiolate-protected gold nanoparticles using Bunte salts as ligand precursors: Investigations of ligand shell formation and core growth”

M.S. Chemistry, Idaho State University (2005)

B.S. Chemistry, Idaho State University (2005)

B.S. Biochemistry, Idaho State University (2003)

Professional Experience

Associate Professor, Chemistry, Colorado Mesa University (2014-2020)

Postdoctoral Researcher, University of Illinois Urbana-Champaign (2011-2014)

Research Interests

Dr. Lohse’s research seeks to establish the connection between the chemical composition and the environmental behavior of emerging nanoscale and microscale contaminants, including engineered nanoparticles and microplastics. Current research projects look specifically at the connections between nanoparticle surface chemistry and protein corona formation, the interactions between nanoparticles and natural organic matter, and developing convenient high-throughput strategies to detect and quantify engineered nanoparticles and microplastics in the environment.

Selected Publications

• Daly Jr, C.A.; Allen, C.; Rozanov, N.; Chong, G.; Melby, E.S.; Kuech, T.R.; Lohse, S.E.; Murphy, C.J.; Pedersen, J.A.; Hernandez, R. Surface coating structure and its interaction with cytochrome c in EG6-coated nanoparticles varies with surface curvature. Langmuir 2020, 36, 5030-5039.
• Kharazian, B.; Lohse, S.E.; Ghasemi, F.; Raoufi, M.; Saei, A.A.; Hashemi, F.; Farvadi, F.; Alimohamadi, R.; Jalai, S.A.; Shokrgozar, M.A.; Hadipour, N.L.; Ejtehadi, M.R.; Mahmoudi, M. Bare surfaces of gold nanoparticle induces inflammation through unfolding of plasma fibrinogen. Scientific Reports, 2018 8, 12557.
• Lohse, S.E. “Size and Shape-Controlled Synthesis of Metal Nanoparticles in Millifluidic Reactors.” Nanomaterial Synthesis: A Practical Guide. C.S.S.R. Kumar, editor. De Gruyter Publishing. 2020. (Book Chapter)
• Lohse, S.E.; Abadeer, N.; Zoloty, M.; Newman, L.A.; White, J.C., Murphy, C.J. Nanomaterial probes in the environment: Gold nanoparticle soil retention and environmental stability as a function of surface chemistry. ACS Sustainable Chem Eng 2017, 5, 11451.
• Lohse, S.E.;* Melby, E.S.;* Park, J.-Y.; Murphy, C.J.; Pedersen, J.A. “Cascading bioeffects of nanoparticle functionalizations: Surface chemistry dictates protein corona composition and subsequent interaction with model cell membranes.” ACS Nano 2017, 11, 5489.
• Mahmoudi, M.; Lohse, S.E.; Murphy, C.J.; Suslick, K.S. Identification of nanoparticles with a colorimetric sensor array. ACS Sensors 2016, 1, 17.
• Melby, E.S.; Mensch, A.C.; Lohse, S.E.; Hu, D.; Orr, G.; Murphy, C.J.; Hamers, R.J.; Pedersen, J.A. Formation of supported lipid bilayers containing phase-segregated domains and their interaction with gold nanoparticles. Environ Sci: Nano 2016, 3, 45-55.
• Dominguez, G.A.; Lohse, S.E.; Torelli, M.D.; Murphy, C.J.; Hamers, R.J.; Orr, G.A.; Klaper, R.D. Differences in molecular interaction of nanomaterials with the gut of Daphnia magna: Changes in charge and ligand surface chemistry impacts cellular, oxidative stress and gene expression. Aquatic Toxicol 2015, 162, 1.
• Troiano, J.M.;  Olenick, L.L.; Kuech, T.R.; Melby, E.S.; Hu, D.; Lohse, S.E.; Mensch, A.C.; Donangun, M.; Vartanian, A.M. et al. Direct probes of 4 nm-diameter gold nanoparticles interacting with supported lipid bilayers. J Phys Chem C 2015, 119, 534.
• Bozich, J.; Lohse, S.E.; Torelli, M.; Hamers, R.J.; Murphy, C.J.; Klaper. R.D. Acute and chronic toxicity of functionalized gold nanoparticles in D. Magna. Environ Sci. Nano 2014, 1, 260-270.
• Lohse, S.E.; Burrows, N.D.; Scarabelli, L.; Liz-Marzan, L.M.; Murphy, C.J. Anisotropic noble metal nanocrystal growth: The role of halides. Chem. Mater. 2013, 26. 34-43.
• Mahmoudi, M.; Lohse, S.E.; Murphy, C.J.; Suslick, K.S. Variation of protein corona composition following plasmonic heating of gold nanoparticles. Nano Lett. 2014, 14, 6-12.
• Lohse, S.E.; Eller, J.R.; Sivapalan, S.T.; Plews, M.R.; Murphy, C.J. A simple millifluidic benchtop reactor for the high-throughput synthesis and functionalization of gold nanoparticles with different sizes and shapes. ACS Nano 2013, 7, 4135-4150.
• Lohse, S.E.; Murphy, C.J. The quest for shape control: A history of gold nanorod synthesis. Chem. Mater. 2013, 25, 1251-1260.
• Lohse, S.E.; Dahl, J.A.; Hutchison, J.E. Direct synthesis of large water-soluble functionalized gold nanoparticles using Bunte salts as ligand precursors. Langmuir 2010, 26, 7504.
• Lohse, S.E.; Rosentreter, J.J. Photooxidation of aqueous trichloroethylene using a buoyant photocatalyst with reaction progress monitored via micro-headspace GC/MS. Microchemical Journal 2006, 82, 66.