Assistant Professor, Biochemistry
Phone: (509) 963-2830
- 2002 - Ph.D. Biochemistry, University of Notre Dame; Advisor: Dr. Paul W. Huber
- 1995 - B.S. Chemistry and Biology, Eastern Washington University
- Sept. 2009 - present, Assistant Professor, Department of Chemistry, Central Washington University
- Oct. 2004 - Sept. 2009, Postdoctoral Research Associate, Molecular Neurobiology Laboratory, Salk Institute for Biological Studies; Advisor: Dr. Dennis D.M. O'Leary
My research interest is focused on understanding the mechanism mediating the partitioning of functional areas in the neocortex in mice. Neocortex is a mammalian-specific cortical structure that is the seat of consciousness. This structure is divided into discrete regions, called areas, that are each responsible for processing different types of information. For example, the visual area of neocortex processes information brought in from the eyes and the motor area makes decisions related to body movements.
The visual, motor and other functional areas are positioned in equivalent locations between individuals and different species, including humans; however, the size of these areas varies between individuals. Neurons in each of these functional areas have specific properties that are bestowed upon them when they are born. The properties that neurons located indifferent areas take on are regulated by the graded expression of several transcription factors (a type of protein that regulates the turning on and off of genes) in the progenitor cells. My group is researching protein-protein interactions mediating the action of this core group of transcription factors in neocortical arealization (the process that determines the sizes of neocortical areas). The ultimate goal of this research is to provide stem cell biologists with information that they can use to generate neurons to repair damaged neocortex in human brain trauma patients.
- Chou. S.J., Perez-Garcia, C.G., Kroll, T.T. and D.D.M. O'Leary (2009) Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Nat Neurosci. (In Press - Nov. 2009).
- Kroll, T.T., L.B. Swenson, E.I. Hartland, D.D. Snedden, H.V. Goodson, and P.W. Huber. (2009) Interactions of 40LoVe within the ribonucleoprotein complex that forms the localization element of Xenopus Vg1 mRNA. Mech Dev. 126(7):523-38.
- O'Leary D.D.M. and T.T.Kroll. (2009) Neural Patterning: Arealization of the Cortex. In: Squire LR (ed.) Encyclopedia of Neuroscience, volume 6, pp. 189-197. Oxford: Academic Press.
- Leingartner, A., S. Thuret, T.T. Kroll, S-J. Chou, J.L. Leasure, F.H. Gage and D.D.M. O'Leary. (2007) Cortical area size dictates performance at modality-specific behaviors. PNAS104(10): 4153-8.
- Kroll, T.T. and D.D.M. O'Leary. (2005) Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate. PNAS102(20): 7374-9.
- Kroll, T.T., W. Zhao, C. Jiang and P.W. Huber. (2002) A homolog of FBP2/KSRP binds to localized mRNAs in Xenopus oocytes. Development 129: 5609-19.
- Zhao, W., C. Jiang, T.T. Kroll, and P.W. Huber (2001) A proline-rich protein binds to the localization element of Xenopus Vg1 mRNA and to ligands involved in actin polymerization.EMBO J. 20(9): 2315-25.
- Bowers, N., T.T. Kroll, and J.R. Pratt (1998) Diversity and geographic distribution of riboprints from three cosmopolitan species of Colpoda Muller (Ciliophora: Colpodea). Europ. J. Protistol. 34: 341-7.