NUTR 543
Advanced Nutritional Biochemistry

David L. Gee, PhD
Professor of Food Science & Nutrition
Department of Health, Human Performance, and Nutrition
Central Washington University


Course Syllabus
Grading Policy
Course Schedule
Case Study Presentation
Course Schedule


Course Syllabus


COURSE DESCRIPTION: Advanced study of the effects of micro- and macro- nutrients on human metabolism. Linkage of this information to the role of nutrition in long-term health and the prevention and treatment of disease.

COURSE OBJECTIVE: Apply current research information of nutrition and metabolism to the practice of dietetics.

Office: 109 HHPN Building
Phone Number: 963-2772
E-mail address:

Textbook:  Metabolism. 1st edition.  Carole J. Coffee.  1998. Fence Creek Publishing.
                This book is currently out of print.  The required readings are available at the Copy Shop.

                Metabolism at a Glance.  J.G. Salway., 3rd ed. , Blackwell Publishing, 2004 (optional)
                (same textbook that was used in NUTR 443- Nutrition II this past year)

Learner Outcomes

1.    The student will be able to describe the regulation of carbohydrate and lipid metabolism as they are affected by different physiological states.

2.    The student will be able to describe the process of protein catabolism with an emphasis on amino acid nitrogen disposal.

3.    The student will be able to apply this knowledge by presenting a professional presentation of a clinical case study.

Grading Policy
Exam 1:
covers Carbohydrate Metabolism (Chapters 8, 9, 11, 12, 13, 14) 
100 points
Exam 2:
covers Fat and Protein Metabolism (Chapters 19, 20, 21, 23)
100 points
Exam 3:
covers Protein Metabolism and case studies (chapter 25)
100 points
Case Study (50% peer evaluation, 50% instructor evaluation - includes quality of questions) 100 points
Total 400 points


Case Study Presentations
Each student has been assigned to present (as a team) a case study.  Prepare to give a 30 minute presentation on your case study.  Your presentation should include an overview of the case, a review of the metabolic aspects of the case, and the nutritional implications of the case.  Each person on the team will present an equal portion of the case.  Evaluation will be on the entire presentation with equal points being given to both members of the team.  One half of the grade will be based on evaluations by your peers and one half by your instructor.  The evaluation will be based on the following scoring system:
Clarity of presentation Were the concepts presented to you in a clear and concise manner? 15 points
Ability to answer questions Did the presenters display adequate knowledge to answer questions related to the case study? 10 points
Use of visual aids Did the presenters use visual aids (whiteboard, overheads, Powerpoint slides) effectively to assist in the transmission of knowledge? 10 points
Overall quality of presentation 15 points
TOTAL 50 points

Format of Case Study Presentation
I. Overview of Case Study
II. Background Information
        A.  Reviews the biochemical and metabolic information that is relevant to this particular case study
III. Case Study Presentation
        A.  Application of biochemical/metabolic information to case study
        B.  Nutritional/dietary factors relevant to case study
        C.  Nutritional care/treatment and rationale

Required Written Material

1. Learning Objectives
        a.  What essential concepts should the learner gain from listening to your presentation?
        b.  Learning Objectives should be presented to the class as a handout and/or overhead projection

2. Multiple choice questions
        a.  Presenters shall prepare 6 multiple choice questions that aid in determining whether learning objectives were met.
        b.  Questions should be challenging and require that the learner was able to answer the question because of your
             case presentation
        c.  Please submit your questions as a Word document attached to an email to

3. Acknowledgment of Student Judicial Code regarding proscribed academic conduct
        a.  Student shall sign the following statement:  I acknowledge the Student Judicial Code (WAC 106-120) which
               recognizes the importance of academic integrity and certify that these submitted questions have not
               been shared with any other student in the class other than members of  my presenting team

4. These written materials are to be turned in the day of your presentation.

Case Study Topics
Case Study - Pyruvate Dehydrogenase Deficiency
Case Study - Von Gierke's Disease
Case Study - Hypoglycemia  
Case Study - Fructose Intolerance
Case Study - Secondary Prevention of Coronary Heart Disease 
Case Study - Alcoholic hepatitis 
Case Study - Protein Catabolism and Trauma 
Case Study - Phenyketonuria
Case Study - Homocystinuria

Course Schedule

Week One
Regulation of Metabolism (Chapter 8)   (Powerpoint slides)
Overview of Carbohydrate Metabolism (Chapter 9)  (Powerpoint slides)
Glycolysis (Chapter 11)  (Powerpoint slides)

Week Two
Glycogen Metabolism (Chapter 12) (Powerpoint slides)
Gluconeogenesis (Chapter 13, MAAG: Chapter 23) (Powerpoint slides)
Pentose Phosphate Pathway (Chapter 14, MAAG: Chapter 12) (Powerpoint slides)

Week Three
Exam 1 (Carbohydrate Metabolism) (Monday, July 2)
Lipid Transport (Chapter 19)

Week Four
Fatty Acid Metabolism (Chapter 20)
Cholesterol and Sterol Metabolism (Chapter 21)
Pathways of Lipid Metabolism (Chapter 23)

Week Five
Exam 2 (Lipid Metabolism) (Monday July 16)
Amino Acid Catabolism (Chapter 25) (Powerpoint slides)
Protein metabolism
Case Study Presentations

Week Six
Case Study Presentations
Exam 3 (Protein Metabolism and Case Studies) (Thursday, July 26)