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Carin Thomas : Mitochondrion Diagram
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Superoxide anion radical is produced by the mitochondrial electron transport chain. Superoxide then undergoes dismutation non-enzymatically or enzymatically via the manganese containing enzyme superoxide dismutatse (MnSOD) to produce hydrogen peroxide. Hydroxyl radical is produced from hydrogen peroxide via the iron-dependent reaction shown below. The actual iron ligand in this reaction is unknown.

Image of mitochondrion

H2O2+ Fe2+(ligand)----->.OH + OH -+ Fe3+(ligand)


Key
Formula Description
O2. - superoxide anion radical
H2O2 hydrogen peroxide
.OH hydroxyl radical
Contact Information
Chemistry Department
Attn: Carin Thomas 400 E. University Way
Ellensburg, WA 98926-7539
(509) 963-2815
email: cthomas@cwu.edu
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