Phone: (509) 963-2815
Fax: (509) 963-1050
Email: cthomas@cwu.edu
- 1991 - PhD Biochemistry University of Nevada, Reno
- 1986 - MA Biology California Single Subject Teaching Credential
in Life Science Humboldt State University, Arcata, CA
- 1983 - BA Botany and BA French Humboldt State University, Arcata,
CA
- 2001- present: Associate Professor, Department of Chemistry,
CWU.
- 1995- 2001: Assistant Professor, Department of Chemistry, CWU.
- 1993-1995: 1993-1995 Faculty Research Associate,
Department of Biochemistry and Biophysics Oregon State
University, Corvallis, OR 97331.
- 1991-1993: Research Fellow, Department of Pathology, Free Radical
Research Unit, Christchurch School of Medicine, Christchurch, New
Zealand.
My research interest lie in the bio activation and cytotoxic mechanisms
of xenobiotics including antineoplastic agents, environmental contaminants,
natural products and photosensitizers. The cytotoxic mechanisms of
interest include, but are not limited to, oxygen activation and toxicity.
Oxygen toxicity involves the generation of chemical species such as
superoxide anion radical, singlet oxygen, hydrogen peroxide and hydroxyl
radical. Aerobic organisms have engineered defenses against the
deleterious effects of these species. Under conditions of persistent
production, however, the normal body defenses may be overwhelmed causing
a metabolic state called oxidative stress. My interests in the toxicity
of xenobiotics and oxygen radicals include the beneficial effects of such
defenses as the antioxidant vitamins, enzymes, and glutathione. Recent
work focuses on the effects of xenobiotics on mitochondrial function.
Since mitochondria are an important source of
oxygen radical species, we are also characterizing the conditions under which hydroxyl radical is formed in
this organelle.
- Thomas C, Will Y, Schoenberg SL, Sanderlin D, and Reed DJ.
Conjugative metabolism of 1,2-dibromoethane in mitochondria:
disruption of oxidative phosphorylation and alkylation of mtDNA.
Biochem Pharmacol 61:595-603, 2001.
- Vissers, MC and Thomas, C. Hypochlorous acid disrupts the
adhesive properties of subendothelial matrix. Free Radic Biol
Med 23(3):401-411, 1997.
- Thomas C, Carr AC, and Winterbourn CC. Free radical inactivation
of rabbit muscle creatine kinase: catalysis by physiological and
hydrolyzed ICRF-187 (ICRF-198) iron chelates. Free Radical
Research 21: 387-397, 1994.
- Thomas C, Vile GF, and Winterbourn CC. The hydrolysis product of
ICRF-187 promotes iron-catalyzed hydroxyl radical production via
the Fenton reaction. Biochem Pharmacol 45: 1967-1972,
1993.
- Elliott AE, Scheiber SA, Thomas C, and Pardini RS. Inhibition of
glutathione reductase by flavonoids: a structure-activity study.
Biochem Pharmacol 44: 1603-1608, 1992.
- Thomas C and Pardini RS. Oxygen dependence of hypericin-induced
phototoxicity to EMT6 mouse mammary carcinoma cells. Photochem
Photobiol 55: 831-837, 1992.
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