David Lygre, Ph.D.

Professor, Biochemistry

Phone: (509) 963-2817
Fax: (509) 963-1050
Email: lygred@cwu.edu

Education:

• 1968-70 - Postdoctoral Fellow: Case Western Reserve University.
• 1968 - Ph.D. in Biochemistry: University of North Dakota.
• 1964 - B.A. in Chemistry: Concordia College (Moorhead, MN).

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Research Interests:

Enzymology of carbohydrate metabolism

The enzyme glucose 6-phosphatase plays a central role in carbohydrate metabolism and in the regulation of blood glucose levels. Work in my group has focused on the effects of inhibitors of this enzyme, both in normal and diabetic conditions, and in efforts to isolate this enzyme from various sources.

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Recent Publications:

• Lygre, D.G. (1995) General, Organic, and Biological Chemistry, 1st edn, Brooks/Cole.
• Miller, G.T. and D.G. Lygre Chemistry: A Contemporary Approach, 2nd edn (1987) and 3rd edn (1991), Wadsworth.
• Lygre, D.G. (1988) "A Little Ado About Nearly Nothing: A Microexperiment on a Picoproblem," ACS Abstr. 94. Presented at the 43rd Annual NW Regional American Chemical Society Meeting.
• Walls, M.A. and D.G. Lygre (1980) "Inhibition by orthophosphate esters of glucose 6-Phosphatase," can. J. Biochem. 58:673-676.
• Lygre, D.G. (1976) "Inhibition by saccharin of glucose 6-phosphatase: effects of alloxan in vivo and deoxycholate in vitro," Can. J. Biochem. 54:587-590.

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