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 Phone: (509) 963-2887
Fax: (509) 963-1050
Email: FabryL@cwu.edu
Office: Science Building 302J
- 2001 - Ph.D. Organic Chemistry, Washington State University
- 2000 - M.S. Chemistry, Washington State University
- 1997 - B.A. Anthropology, Washington State University
- 1996 - B.S. Biochemistry, Washington State University
- Sept. 2003 - Present, Assistant Professor, Department of Chemistry, Central Washington University
- Aug. 2001 - Aug. 2003, Post-doctoral Research Associate, Department of Chemistry/School of Pharmacy, University of Wisconsin
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- My research
group is interested in addressing
biologically and medically important questions.
The focal point of our research is the design
and synthesis of small molecule inhibitor
scaffolds against therapeutically important
enzymes. Our goal is to find orally active
inhibitors that could become lead compounds
for further drug discovery. During this
process, we are developing new and improving
already known synthetic chemistry methodologies.
To achieve our goals we use all the modern
tools of medicinal chemistry and organic
synthesis. We are developing inhibitor scaffolds
against enzymes responsible for the proliferation
of disease states such as HIV/AIDS, cancer,
and malaria.
- Also, as a joint
research effort with a computer science group we develop and extensively test new molecular modeling and computational chemistry techniques. This endeavor centers on molecular modeling, as well as computational intelligence techniques, which include neural networks, fuzzy systems, evolutionary computation, and biology inspired computational models.
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- "A Genetic Algorithm Optimized Fuzzy Neural Network Analysis of the
Affinity of Inhibitors for HIV-1 Protease" Levente Fabry-Asztalos,
Razvan Andonie, Catharine J. Collar, Sarah Abdul-Wahid, Nicholas Salim,
Bioorganic & Medicinal Chemistry, 2008, 2903-2911
- "A New Fuzzy ARTMAP Approach for Predicting Biological Activity of
Potential HIV-1 Protease Inhibitors" Razvan Andonie, Levente
Fabry-Asztalos, Lukas Magill, Sarah Abdul-Wahid Proceedings of the IEEE
International Conference on Bioinformatics and Biomedicine (BIBM 2007),
2007, 56-61.
- "An Integrated Soft Computing Approach for Predicting Biological Activity of Potential HIV-1 Protease Inhibitors" Andonie, R.; Fabry-Asztalos, L.; Abdul-Wahid, S.; Collar, C. J.; Salim, N. Proceedings of the IEEE International Joint Conference on Neural Networks, 2006, 7495-7502.
- "Neuro-fuzzy Prediction of Biological Activity and Rule Extraction for HIV-1 Protease Inhibitors" Andonie, R.; Fabry-Asztalos, L.; Collar, C. J.; Abdul-Wahid, S.; Salim, N. Proceedings of the IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, San Diego, 2005, 113-120.
- "Glass Catalyzed Conversion of Boronic Esters of Asymmetric Diols to Diol Sulfites and Amine Complexes of Boron Halides," Matteson, D.S.; Hiscox, W.C.; Fabry-Asztalos, L.; Kim, G.; Siems, W.F. III. Organometallics, 2001, 20, 2920-2923.
- "Efficient Syntheses of Fluorinated Aryl Alcohols of High Enantiomeric Purity via Boronic Esters," Singh, R. P.; Twamley, B.; Fabry-Asztalos, L.; Matteson, D. S.; Shreeve, J. M.J.Org. Chem., 2000, 65, 8123-8125.
- "Inhibition of HIV-1 Protease by a Boron-Modified Polypeptide," Pivazyan, A. D.; Matteson, D. S.; Fabry-Asztalos, L.; Singh, R. P.; Lin, P; Blair, W.; Guo, K; Robinson, B.; Prusoff, W. H. Biochem.
Pharma., 2000, 60, 927-936.
- "Preparation of borinic acid peptide derivatives as protease inhibitors," Matteson, D. S.; Fabry-Asztalos, L.; Prusoff, W. H.; Pivazyan, A. D. PCT Int. Appl. 2003, 50 pp., CODEN:PIXXD2 WO 0315706 A2 20030227 CAN 138:188075 AN 2003: 154193.
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