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Chemistry

Young Kim

Lecturer, Organic Chemistry

Phone:  509-963-2022
Fax:  509-963-1050
Email:  ykim@cwu.edu
Office Science-207F

EDUCATION

2008 - Ph.D. in Pharmaceutical Sciences emphasis in Medicinal Chemistry; University of Mississippi, University, MS.  Advisor:  Dr. John M. Rimoldi   

2001 - B. A. in Biology, cum laude, University of Mississippi, University, MS.  Advisor:  Dr. Clifford A. Ochs

EXPERIENCE

  • 2009- 2013:  Post-Doctoral Fellow, Moffitt Cancer Center.
  • 2010:  Judge for 8th Annual Castle Conference, held at the University of South Florida, Tampa, FL.
  • 2008- 2009:  Post-Doctoral Research Associate, Texas A&M University
  • 2002- 2008:  Graduate Research Assistant, University of Mississippi
  • 2003- 2004:  Senator, Graduate Students Council, University of Mississippi
  • 2002- 2003:  President, Korean Student Association, University of Mississippi
  • 2002:  Graduate Teaching Assistant, Principles of Medicinal Chemistry, University of Mississippi

 

PEER-REVIEWED PUBLICATIONS

  • Kim, Y.B. and Rimoldi, J. M.  Protein Kinase C Inhibitors, Perspectives in Medicinal Chemistry, Invited Review, in progress, 2013.
  • Kim, Y.B., Odom, L.O., Rimoldi, J. M.  Asymmetric synthesis of Jaspine B and  related analogs derived from L-Serine amino acid.  Tetrahedron, in progress, 2013.
  • Kim, Y.B., Balasis M.E., Doi K., Berndt N., DuBoulay C., Hu C.A., Guida W., Wang H.G., Sebti S.M., Del Valle J.R. Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1.BimBH3 interaction. Bioorganic & Medicinal Chemistry Letters (2012) 22, 5961.
  • Kim, Y.B. and Del Valle J.R. Synthesis of a diversifiable cis-didehydrodecalin scaffold based on meiogynin A. Tetrahedron Letters (2011) 52, 6396- 6398.
  • Kamel, H.N., Kim, Y.B., Rimoldi, J.M., Fronczek, F.R., Ferreira, D.,  Slattery, M. Scalarane Sesterterpenoids: Semisynthesis and Biological Activity. Journal of Natural Products (2009) 72(8), 1492- 1496.
  • Sufka, K.J., Warnick, J.E., Pulaski, C.N., Slauson,S.R., Kim, Y.B., Rimoldi, J.M. Antidepressant efficacy screening of novel targets in the chick anxiety-depression model. Behavioural Pharmacology (2009) 20(2), 146-154. 

SCIENTIFIC ABSTRACTS and PRESENTATIONS

  • Kim, Y.B., Chang Won Kang, and J. R. Del Valle. Peptidomimetic Inhibitors of Akt and SGK targeting the substrate binding domain. 23rd American Peptide Symposium, Hawaii, June, 2013.
  • Kim, Y.B., Chang Won Kang, Sujeewa Ranatunga, Hua Yang, Sebti S.M., and Del Valle J. R. Design and synthesis of substrate mimetic Akt inhibitors based on the structure of GSK3. Moffitt Scientific Symposium, Tampa, FL, May, 2013.
  • Kim, Y.B., Doi K., DuBoulay C., Guida W., Sebti S.M., Hu, C.A., and Del Valle J.R. Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1.BimBH3 interaction. Gordon Research Conference Bioorganic Chemistry, Andover, NH, June, 2012.
  • Kim, Y.B., Doi K., DuBoulay C., Guida W., Sebti S.M., Hu C.A., and Del Valle J.R. Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1.BimBH3 interaction. Moffitt  Scientific Symposium, Tampa, FL, May, 2012.
  • Warnick, J.E., Pulaski, C., Slauson, S.R., Kim, Y.B., Rimoldi, J.M., and Sufka, K.J. Antidepressant efficacy screening of novel targets in the chick anxiety-depression model.  38th annual meeting of the Society of Neuroscience. Washington, D.C., November 15-19, 2008.  
  • Kim, Y.B. and Rimoldi, J. M. A general application of metal carbenoid reactions toward natural product synthesis and chiral building blocks. 1st Annual Meeting of Biotage Summer Program, held in Richmond, VA, July 21- 23, 2008.
  • Kim, Y.B. Heteroatom insertion reactions of metal carbenoids: chiral building blocks for natural product synthesis. MALTO Medicinal Chemistry and Phamacognosy Meeting, held in Monroe, Louisiana, May 20-22, 2007.
  • Kim, Y.B.  Heteroatom insertion reactions of rhodium carbenoids derived from   O-and S-tert-Butyl protected -amino-diazoketones. MALTO Medicinal Chemistry and  Phamacognosy Meeting, Oxford, Mississippi, May 22-24, 2005.
  • Odom, L., Kim, Y.B., and Rimoldi, John M. Synthesis of chiral tetrahydrofuranones, tetrahydrothiophenones, and azetidinones via rhodium (II) catalyzed cyclization reactions. 228th ACS National Meeting, Philadelphia, PA United States, August 22-26, 2004.
  • Kim, Y.B.  Synthesis of novel azetidines: Solution and solid-phase approaches. MALTO Medicinal Chemistry and Phamacognosy Meeting, Little Rock, Arkansas, May 18- 20, 2003.
  • Kim, Y.B. and Rimoldi J.M. Synthesis of novel azetidines as potential PKC inhibitors: Solution and solid-phase approaches.  Sigma Xi and Office of Research Student Poster Symposium, Oxford, Mississippi, United States, April 2, 2003.
  • Kim, Y.B., Beeler A.B., and Rimoldi J.M. Synthesis of novel azetidines as potential PKC inhibitors: Solution and solid-phase approaches. 225th ACS National Meeting, New Orleans, LA, United States, March 23-27, 2003.