Phone: (509) 963-1126
Fax: (509) 963-1050
My research interests begin with pioneering new chemical methods and improving extant synthetic methods to make them useful. The application of many reported synthetic methods is hampered by a lack of substrate generality, poor yield in all but a few select examples, and metal-mediated reactions that are catalytic and asymmetric with respect to the metal/ligand complex, but are wasteful in other aspects. Along with the development of new and improved methods, I will undertake the total synthesis of structurally intreguing and biologically active natural products. I am also driven to broaden the use of computational chemistry in the synthetic arena by using it as a predictive tool used to plan natural product syntheses and also to rationalize the sometimes surprising stereochemical and regiochemical outcomes that befall synthetic chemists, often necessitating a change in strategy. Projects in my group will initially involve the design of new, better, and more environmentally friendly catalytic, asymmetric reactions to form nitrogen-containing three-membered rings, as well as pioneering new chemistry involving HOMO(Highest Occupied Molecular Orbital)-raising chiral auxiliaries in reactions such as the Diels-Alder [4 + 2] cycloaddition.