Dr. Wayne S. Quirk, Professor

Biological Sciences Department
Science Building, Room 338F

400 E. University Way
Ellensburg, WA 98926-7537
(509) 963-2825
quirkw@cwu.edu

EDUCATION

Ph.D. (Experimental Psychology and Physiology) – 1988, Washington State University
M.S. (Industrial Relations) – 1982, Iowa State University
B.S. (Psychology) – 1980, University of Northern Iowa

PROFESSIONAL APPOINTMENTS

Central Washington University, Ellensburg, WA
Professor of Biological Sciences (2012-present)
Provost and Vice President for Academic and Student Life (2008-2011)
Associate Vice President for Graduate Studies and Research (2003-2008)

Minnesota State University, Mankato, MN
Director of Research (1997-2003)
Professor of Communication Disorders (1997-2003)

Wayne State University, Detroit, MI
Associate Professor and Director of Research, Department of Otolaryngology (1995-1997)
Assistant Professor, Department of Otolaryngology (1991-1995)

The University of Michigan, Ann Arbor, MI
Post-Doctoral Fellow (1988-1991)

TEACHING EXPERIENCE

• Introduction to Psychology
• Research Methods
• Statistics
• Biopsychology
• Seminar in Communication Disorders
• Seminars in Auditory Physiology and Neuroscience
• Human Physiology
• Anatomy and Physiology
• Sensory Physiology Seminar

NATIONAL RESEARCH SERVICE

• NIH NIDCD RO1, study section ad hoc     
• NIH NIDCD R21, study section
• NIH NIDCD Biology of Noise-Induced Hearing Loss workshop, invited presenter
• NIH NIDCD Small Business Innovation Research Program, study section
• NIH NIDCD R03, study section
• NIH NIDCD RO1, study section
• Professional Journal service
CNS Drugs, reviewer
  Otolaryngology—Head and Neck Surgery, Editorial Review Board
  Hearing Research, reviewer

RESEARCH FUNDING

Autoregulation of cochlear blood flow
NIHDCD Postdoctoral Fellowship 1F32NS08546 01
Principal investigator: W. S. Quirk
Mentors: A. L. Nuttall and J. M. Miller
Total annual costs: $21,000 (December 1, 1988 July 31, 1991)

Sound-induced changes in cochlear blood flow
NIH R29 DC001745
Principal investigator: W. S. Quirk
Total costs: $517,072 (1993-2001)

Research training in otolaryngology
NIH T32 Training Grant
Principal investigator: R. H. Mathog
Co-investigator: W. S. Quirk
Total costs: $863,482 (July 1, 1992-June 30, 1997)

Cochlear blood flow in normotensive and spontaneously hypertensive rats
Deafness Research Foundation
Principal investigator: W. S. Quirk
Total costs: $45,000 (January 1, 1988-December 31, 1991)

The role of endothelin on cochlear blood flow and cochlear electrophysiology
Deafness Research Foundation
Principal investigator: W. S. Quirk
Co-investigators: E. L. Laurikainen and B. G. Goldwyn
Total costs: $30,000 (January 1, 1992-December 31, 1993)

Peptidergic system during noise exposure
AAO-HNS Resident Research Award
Principal investigator: B. G. Goldwyn
Mentor: W. S. Quirk
Total costs: $9,983 (July 1, 1993-June 30, 1995)

Vestibular blood flow during natural stimulation
American Otologic Society
Principal investigator: T. D. Doerr
Mentor: W. S. Quirk
Total costs: $40,000 (July 1, 1996-June 30, 1998)

Regulation of vestibular blood flow in endolymphatic hydrops
AAO-HNS Resident Research Award
Principal investigator: P. Reddy
Mentor: W. S. Quirk
Total costs: $10,000 (July 1, 1997-June 30, 1998)

Undergraduate Research Conference
Bush Foundation, Learning by Doing Initiative
Principal investigator: W. S. Quirk
Total costs: $41,410 (July 1, 2000-2001)

Undergraduate research and creative activities
Bush Foundation, Learning by Doing Initiative
Principal investigator: W. S. Quirk
Total costs: $49,400 (2001-2003)

PUBLICATIONS

Manuscripts
Wright JW, Sullivan MJ, Quirk WS, Batt CM, Harding JW. Heightened blood pressure and drinking responsiveness to intracerebroventricular angiotensins in spontaneously hypertensive rats. Brain Research. 1986;420(2):289 294.

Quirk WS, Wright JW, Harding JW. Amastatin and bestatin induced dipsogenicity in the Sprague Dawley rat. Brain Research Bulletin.1987;19(1):145 147.

Wright JW, Quirk WS, Hanesworth JM, Harding JW. Influence of aminopeptidase inhibitors on brain angiotensin metabolism and drinking in rats. Brain Research. 1987; 441:215 220.

Quirk WS, Wright JW, Harding JW.  Tachyphylaxis of dipsogenic activity intracebroventricular administration of angiotensins. Brain Research. 1988;452(1-2):73 78.

Quirk WS, Dengerink HA, Wright JW, Miller JM. Angiotensin induced changes in cochlear flow and cochlear blood pressure in normotensive and spontaneously hypertensive rats. Hearing Research. 1988;33(2):129 135.

Quirk WS, Dengerink HA, Bademian MJ, Hall KW, Wright JW. The effects of pentoxifylline on cochlear blood flow in normotensive and spontaneously hypertensive rats. Hearing Research. 1988;36(2-3):175 180.

Quirk WS, Dengerink HA, Harding JW, Bademian MJ, Swanson SJ, Wright JW. Autoregulation of cochlear blood flow in normotensive and spontaneously hypertensive rats following intracerebroventricularly mediated adjustment of blood pressure. Hearing Research. 1989;38(1-2):119 123.

Quirk WS, Dengerink HA, Coleman JK, Wright JW. Cochlear blood flow autoregulation in Wistar Kyoto rats. Hearing Research. 1989;41(1):53 60.

Harding JW, Jensen LL, Quirk WS, Dewey A, Wright JW. Brain angiotensin: A critical role in the ongoing regulation of body fluid homeostasis and cardiovascular function. Peptides. 1989;10:261 264.

Flynn AJ, Quirk WS, Dengerink HA, Wright JW. The effects of intracerebroventricularly administered angiotensin II on blood pressure and cochlear blood flow in rats and guinea pigs. Hearing Research. 1989;41(2-3):249 254.

Quirk WS, Bademian MJ, Dengerink HA, Wright JW. Mannitol and Dextran increase cochlear blood flow in normotensive and spontaneously hypertensive rats. Acta Otolaryngologica. 1990;109(5-6):383 388.

Coleman JKM, Quirk WS, Dengerink HA, Wright JW. Pentoxifylline increases cochlear blood flow while decreasing blood pressure in guinea pigs. Hearing Research. 1990;47(1-2):169 174.

Quirk WS, Nuttall AL, Miller JM. Noise induced changes in red blood cell velocity of lateral wall vessels of the rat cochlea. Hearing Research. 1991;52(1):217 224.

Seidman MD, Quirk WS, Nuttall AL, Schweitzer, VG. The protective effects of allopurinol and superoxide dismutase polyethylene glycol on ischemic and reperfusion cochlear damage. Otolaryngology—Head and Neck Surgery. 1991;105(3):457 463.

McClaren GM, Coleman JKM, Quirk WS, Dengerink HA, Wright JW. Influences of intra arterial infusion of arginine vasopressin on cochlear blood flow in the rat. Hearing Research. 1991;55(1):1 8.

Seidman MD, Quirk WS. The protective effects of tirilazad mesylate (U74006F) on ischemic and reperfusion induced cochlear damage. Otolaryngology—Head and Neck Surgery. 1991;105(4):511 516.

Myers MW, Quirk WS, Rizk S, Miller JM, Altschuler RA. Expression of the major mammalian stress protein in the rat cochlea following transient ischemia. Laryngoscope. 1992;102(9):981-987.

Quirk WS, Avinash G, Nuttall AL, Miller JM. The influence of loud sound on red blood cell velocity and blood vessel diameter in the cochlea. Hearing Research. 1992;63(1-2):102-107.

Seidman MD, Quirk WS. The anterior inferior cerebellar arterial network supplying the rat cochlear and its role in autoregulation of cochlear blood flow. European Archives of Oto-Rhino-Laryngology. 1992;249(6):332-335.

Laurikainen E, Nuttall AL, Miller JM, Quirk WS, Virolainen E. Experimental basis for lidocaine therapy in cochlear disorders. Acta Otolaryngologica. 1992;112(5):800-809.

Laurikainen E, Miller JM, Quirk WS, Kallinen J, Nuttall AL, Grenman R, Virolainen E. Betahistine-induced vascular effects in the rat cochlea. American Journal of Otology. 1993;14(1):24-30.

Ren TR, Laurikainen EL, Quirk WS, Miller JM, Nuttall AL. Effects of electrical stimulation of the superior cervical ganglion on cochlear blood flow in guinea pig. Acta Otolaryngologica. 1993;113(2):146-153. 

Laurikainen E, Kim D, Didier A, Miller JM, Quirk WS, Nuttall AL. Stellate ganglion drives sympathetic regulation of cochlear blood flow. Hearing Research. 1993;64(2): 199-204.

Ren TR, Laurikainen EL, Quirk WS, Miller JM, Nuttall AL. Effects of stellate ganglion stimulation on bilateral cochlear blood flow. Annals of Otolaryngology, Rhinology and Laryngology. 1993;102(5):378-384.

Avinash GB, Quirk WS, Nuttall AL. Three-dimensional analysis of contrast filled microvessel diameters. Microvascular Research. 1993;45(2):180-192.

Shivapuja BG, Gu ZP, Saunders SS, Quirk WS. Acute effects of cocaine on cochlear function. Hearing Research. 1993;69(1-2):243-250.

Seidman MD, Shivapuja BG, Quirk WS. The protective effects of allopurinol, superoxide dismutase on noise induced cochlear damage. Otolaryngology—Head and Neck Surgery. 1993;109(6):1052-1056.

McClaren GM, Quirk WS, Laurikainen E, Seidman MD, Coleman JKM, Dengerink HA, Wright JW, Nuttall AL, Miller JM. The role of circulating and locally infused substance P on cochlear blood flow and cochlear electrophysiology. Hearing Research. 1993;71: 183-189.

Quirk WS, Seidman MD, Laurikainen EL, Nuttall AL, Miller JM. Influence of calcitonin gene related peptide on cochlear blood flow and electrophysiology. American Journal of Otology. 1994;15(1):56-60.  

Ren TR, Avinash GB, Nuttall AL, Miller JM, Laurikainen EL, Quirk WS. Dynamic response of cochlear blood flow to occlusion of the anterior inferior cerebellar artery in guinea pigs. Journal of Applied Physiology. 1994;76(1):212-217.

Quirk WS, Shivapuga BG, Seidman MD. Tirlizad mesylate attenuates noise-induced temporary threshold shifts. Hearing Research. 1994;74:217-220.

Laurikainen EA, Costa O, Miller JM, Nuttall AL, Ren TY, Masta R, Quirk WS, Robinson PJ. Neuronal regulation of cochlear blood flow in guinea pig. Journal of Physiology. 1994;480(3):563-573.  

Quirk WS, Coleman JKM, Hainesworth J, Harding JW, Wright JW. Noise-induced elevations of plasma endothelin. Hearing Research. 1994;80(1):119-122.

Quirk WS, Seidman MD. Cochlear vascular changes in response to loud noise. American Journal of Otology. 1995;16(3):322-325.

Rachel JD, Dziadziola JK, Quirk WS. Atrial natriuretic peptide participates in the regulation of vestibular blood flow. Hearing Research. 1995;89:181-186.

Quirk WS, Goldwyn B, Melecca R, Kaltenbach JA. Dorsal cochlear nucleus blood flow during acoustic stimulation. Otolaryngology—Head and Neck Surgery. 1996;114(4):613-619.

Latoni J, Shivapuja BG, Seidman MD, Quirk WS. Pentoxifylline maintains cochlear microcirculation. Acta Otolaryngologica. 1996;116(3): 388-394.

Seidman MD, Kahn MJ, Murphy MP, Quirk WS, Castoro F, Bai U. The association of mitochondrial DNA deletions and cochlear pathology: A molecular biologic tool. Laryngoscope. 1996;106(6):777-783.

Seidman MD, Khan MJ, Dolan DR, Quirk WS. Age-related differences in cochlear microcirculation and auditory brainstem response. Archives of Otolaryngology. 1996; 122(11):1221-1226.

Mandal A, Kaltenbach JA, Quirk WS. Changes in dorsal cochlear nucleus blood flow during noise exposure. Hearing Research. 1997;106(1-2):1-8.

Laurikainen EA, Ren T Y, Miller JM, Nuttall AL, Quirk WS. The tonic sympathetic input to the cochlear vasculature in guinea pig. Hearing Research. 1997;105(1 2): 141 145.

Quirk WS, Bahu SJ, Komjathy DA, Seidman MD. In vivo vestibular blood flow in the Mongolian gerbil: Angiotensin provoked changes in systemic and local factors. Acta Otolaryngologica. 1997;117(4):559-563.

Goldwyn BG, Quirk WS. Calcium channel blockade reduces noise-induced vascular permeability in cochlear stria vascularis. Laryngoscope. 1997;107(8):1112-1116.

Arenberg J, Komjathy DA, Seidman MD, Quirk WS. Local effects of nitric oxide on vestibular blood flow in the Mongolian gerbil. European Archives of Oto-Rhino-Laryngology. 1997;254(8):367-371.  

Seidman MD, Bai U, Khan MJ, Quirk WS. Mitochondrial DNA deletions associated with aging and presbycusis. Archives of Otolaryngology, Head and Neck Surgery. 1997; 123(10):1039-1045.  

Bai U, Seidman MD, Hinojosa R, Quirk WS. Mitochondrial DNA deletions associated with aging and possibly presbyacusis: A human archival temporal bone study. American Journal of Otology. 1997;18(4):449-453.

Burgio, DL, Hazra AS, Komjathy DA, Quirk WS. Guinea pig vestibular blood flow in response to calcitonin gene related peptide. Acta Otolaryngologica. 1997;117(6):819-824.   

Goldwyn B, Shivapuja BG, Seidman MD, Quirk WS. Sarthran preserves cochlear microcirculation and reduces temporary threshold shifts after noise exposure.  Otolaryngology—Head and Neck Surgery. 1998;118(5):576-583.

Laurikainen E, Miller JM, Nuttall AL, Quirk WS. The vascular mechanism of action of betahistine in the inner ear of the guinea pig. European Archives of Oto-Rhino-Laryngology. 1998;255(3):119-123.

Seidman MD, Shirwany NA, Quirk WS. Aging of the cochlea. Current Opinions in Otolaryngology—Head and Neck Surgery. 1998;6:296-300.  

Doerr TD, Dziadziola JK, Komjathy DA, Quirk WS. The effects of pentoxifylline and flunarizine on vestibular blood flow. European Archives of Oto-Rhino-Laryngology. 1998;255(8):385-390.

Dziazoiola JK, Laurikainen E, Rachel JD, Quirk WS. Beta-histine increases vestibular blood flow. Otolaryngology—Head and Neck Surgery. 1999;120(3):400-405.

Seidman MD, Quirk WS, Shirwany NA. Reactive oxygen metabolites, antioxidants and head and neck cancer. Head and Neck. 1999; 21(5):467-479.

Seidman MD, Khan MJ, Bai U, Shirwany NA, Quirk WS. Biologic activity of mitochondrial metabolites on aging and age-related hearing loss. American Journal of Otology. 2000;21(2):161-167.

Khan MJ, Seidman MD, Shivapuja BG, Quirk WS. Effects of kynurenic acid as a glutamate receptor antagonist in the guinea pig. European Archives of Oto-Rhino-Laryngology. 2000;257(4):177-181.

Reddy PG, Burgio DL, Quirk WS. Measurement of peripheral vestibular blood flow in a gerbil model of endolymphatic hydrops. Otolaryngology—Head and Neck Surgery. 2000; 123(1):97-100.

Doerr TD, Blakley BW, Komjathy DA, Quirk WS. Local vestibular blood flow and systemic vascular responses to natural vestibular stimulation in the Mongolian gerbil. Otology and Neurology. 2001;22:242-248.

Seidman, MD, Khan MJ, Tang WX, Quirk WS. Influence of lecithin on mitochondrial DNA and age-related hearing loss. Otolaryngology—Head and Neck Surgery. 2002; 126(3):1-7.

Seidman M, Babu S, Tang W, Naem E, Quirk WS. Effects of resveratrol on acoustic trauma. Otolaryngology—Head and Neck Surgery. 2003;129(5):463-470.

Seidman MD, Ahmad N, Joshi D, Seidman J. Thawani S, Quirk WS. Age-related hearing loss and its association with reactive oxygen species DNA damage. Acta Otolaryngo-logica Suppl. 2004;May:16-24.

Chapters
Quirk WS. Baseball’s big inning: The sacrifice of the 1919 Chicago Black Sox. In: Quirk, CE, ed. Sports and the Law: Major Legal Cases. New York, NY: Garland Publishing, Inc.; 1996:111-120. 

Quirk WS. Fear, attack and pressure: The relocation of the Raiders. In: Quirk CE, ed. Sports and the Law: Major Legal Cases. New York, NY: Garland Publishing, Inc.; 1996:224-232.   

Quirk WS, Doerr TD. Autoimmune sensorineural hearing loss. In: Gilman S, Goldstein GW, Waxman SG, eds. Neurobase. San Diego, Calif: Arbor Publishing Corporation; 1996 (updated in 1997, 1998, 1999 and 2000). 

Seidman MD, Quirk WS, Shirwany NA. Mechanisms of alterations in the micro-circulation of the cochlea. In: Henderson D, Salvi R, Quaranta A, McFaddens T, Burkhard RF, eds. Ototoxicity: Basic Science and Clinical Applications. Annals New York Academy of Sciences. 2000;884:226-232.

PRESENTATIONS

My students, collaborators, and I presented over 70 conference presentations (available on request) at the Society for Neuroscience, Association for Research in Otolaryngology, American Academy of Otolaryngology—Head and Neck Surgery, and Triologic Society.

INVITED LECTURES AND SEMINARS

“Cochlear blood flow regulatory mechanisms,” Fall Seminar Series, Washington State University, October 1989.

“The influence of noise on cochlear microcirculation,” Research Seminar, Henry Ford Hospital, October 1990.

“Cochlear blood flow: Noise and the peptidergic system,” Hearing and Chemical Senses Seminar Series, Kresge Hearing Research Institute, The University of Michigan, September 1991.

“Mechanisms of noise damage,” Fall Seminar Series, University of Texas Tyler, October 1991.

“Noise-induced hearing loss,” Invited Lecture, Wayne County Medical Society, November 1992.

“Prevention of noise-induced hearing loss,” Invited Lecture, Washington State University, September 1994.

“Cochlear microcirculation,” Invited Lecture, Medical University of South Carolina, May 1995.

“Pathophysiology of  noise-induced hearing loss,” Round Table, Karolinska Institute, Stockholm, Sweden, May 1997.

“Vestibular homeostasis,” Invited Lecture, University of Oulu, Oulu, Finland, May 1997.

“Sound-induced changes in cochlear microcirculation,” NIH NIDCD workshop on the biology of noise-induced hearing loss, December 1998.